ABIRATERONE ACETATE BDBM50407398 CB7630 Zytiga
CB 7598 CHEMBL254328 (1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-(pyridin-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,13-dien-5-ol ABT Abiraterone US9487554, Abiraterone BDBM25458 US9611270, Example 5, abiraterone
3-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine Abiraterone mimetic, 8 BDBM25445
4-[6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine Abiraterone mimetic, 17 BDBM25454
4-[6-(4-fluorophenyl)-1H-inden-3-yl]pyridine Abiraterone mimetic, 9 BDBM25446
4-[6-(4-methoxyphenyl)-1H-inden-3-yl]pyridine Abiraterone mimetic, 10 BDBM25447
Abiraterone mimetic, 18 4-[6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine BDBM25455
BDBM25448 Abiraterone mimetic, 11 4-[6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
BDBM25449 Abiraterone mimetic, 12 4-[6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl]pyridine
3-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine Abiraterone mimetic, 15 BDBM25452
4-[5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]pyridine BDBM25453 Abiraterone mimetic, 16
Abiraterone mimetic, 5 BDBM25442 6-(4-fluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol
Abiraterone mimetic, 6 6-(3,4-difluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol BDBM25443
2-fluoro-4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]phenol BDBM25457 Abiraterone mimetic, 20
Abiraterone mimetic, 14 BDBM25451 2-fluoro-4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]phenol
Abiraterone mimetic, 19 4-[5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl]benzene-1,2-diol BDBM25456
BDBM25450 4-[5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl]benzene-1,2-diol Abiraterone mimetic, 13
5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol BDBM25438 Abiraterone mimetic, 1
Abiraterone mimetic, 2 BDBM25439 5-(4-fluorophenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol
Abiraterone mimetic, 3 5-(4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol BDBM25440
Abiraterone mimetic, 7 6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol BDBM25444
5-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol Abiraterone mimetic, 4 BDBM25441
- Pinto-Bazurco Mendieta, MA; Negri, M; Jagusch, C; Müller-Vieira, U; Lauterbach, T; Hartmann, RW Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. J Med Chem 51: 5009-18 (2008)
- Jarman, M; Barrie, SE; Llera, JM The 16,17-double bond is needed for irreversible inhibition of human cytochrome p45017alpha by abiraterone (17-(3-pyridyl)androsta-5, 16-dien-3beta-ol) and related steroidal inhibitors. J Med Chem 41: 5375-81 (1999)